INHIBITION OF GLUTAMINE SYNTHETASE BY PHOSPHINOTHRICIN LEADS TO TRANSCRIPTOME REPROGRAMING IN ROOT NODULES OF MEDICAGO TRUNCATULA

Inhibition of Glutamine Synthetase by Phosphinothricin Leads to Transcriptome Reprograming in Root Nodules of Medicago truncatula

Glutamine synthetase (GS) is a vital enzyme for the assimilation of ammonia into amino acids in higher plants.In legumes, GS plays a crucial role in the assimilation of the ammonium released by nitrogen-fixing bacteria in root nodules, constituting an important metabolic knob controlling the nitrogen (N) assimilatory pathways.To identify new regula

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The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4+ T cells resembling iTreg

BackgroundTreg cells have been shown to be an important part of immune-homeostasis and IL-2 which is produced upon T cell receptor (TCR)-dependent activation of T lymphocytes has been demonstrated to critically participate in Treg development.ObjectiveTo evaluate small molecule inhibitors Twin Metal Day Bed w/Platform (SMI) for the identification o

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Population Pharmacokinetics of CC-122

Yiming Cheng,1 Jian Chen,2 Michael Pourdehnad,3 Simon Zhou,1 Yan Li1 1Clinical Pharmacology & Pharmacometrics, Bristol Myers Squibb, Summit, NJ, USA; 2Non-Clinical Research & Development, Bristol Myers Squibb, Summit, NJ, USA; 3Early Clinical Development, Bristol Myers Squibb, San Francisco, CA, USACorrespondence: Yan LiClinical Pharmacolog

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The Effect of Cutting and Waterlogging on Plant-Related CO2 and N2O Fluxes Associated with the Invasive N-Fixing Species Gunnera tinctoria

The overall impact that plant invasions have on greenhouse gas emissions (GHG) by plant-mediated effects and how these interact with environmental and management factors is largely unknown.To address this, we report on the effects Football Cleats of leaf removal and waterlogging, either singularly or in combination, on the fluxes of CO2 and N2O ass

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